{"entity":{"id":"nct05358249","kind":"trial","name":"Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation","aka":[],"tldr":"A phase 1/2 trial of JDQ443, Trametinib, Ribociclib in non-small-cell lung cancer and small-cell lung cancer, run by Novartis Pharmaceuticals, active and no longer recruiting.","summary":"Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation is a phase 1/2 interventional study registered as NCT05358249 by Novartis Pharmaceuticals, with 74 participants enrolled, started 2022-10-24 and due to reach its primary completion in 2026-09-30. Interventions recorded: JDQ443, trametinib, Ribociclib, cetuximab. Conditions listed: KRAS G12C Mutant Solid Tumors, Carcinoma, Non-Small Cell Lung, Carcinoma, Non-Small-Cell Lung, Non-Small Cell Lung Cancer. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05358249","url":"https://clinicaltrials.gov/study/NCT05358249"}],"tags":["ctgov-ingest"],"related":[],"cancers":["nsclc","sclc","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["jdq443","trametinib","ribociclib","cetuximab"],"companies":["novartis"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05358249","phase":"1/2","setting":"KontRASt-03: A Phase Ib/II, Multicenter, Open-label Platform Study of JDQ443 With Select Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation","sponsor":"Novartis Pharmaceuticals","enrolled":74,"outcomes":[]},"route":"/trials/nct05358249/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"drug":[{"id":"cetuximab","kind":"drug","name":"Cetuximab","route":"/drugs/cetuximab/"},{"id":"jdq443","kind":"drug","name":"JDQ443","route":"/drugs/jdq443/"},{"id":"ribociclib","kind":"drug","name":"Ribociclib","route":"/drugs/ribociclib/"},{"id":"trametinib","kind":"drug","name":"Trametinib","route":"/drugs/trametinib/"}],"company":[{"id":"novartis","kind":"company","name":"Novartis","route":"/companies/novartis/"}]}}