{"entity":{"id":"nct05379985","kind":"trial","name":"Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS","aka":[],"tldr":"A phase 1/2 trial of Daraxonrasib in non-small-cell lung cancer and small-cell lung cancer, run by Revolution Medicines, Inc., now recruiting.","summary":"Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS is a phase 1/2 interventional study registered as NCT05379985 by Revolution Medicines, Inc., with 754 participants planned, started 2022-05-31 and due to reach its primary completion in 2027-05-31. Interventions recorded: RMC-6236. Conditions listed: Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC), Advanced Solid Tumors. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05379985","url":"https://clinicaltrials.gov/study/NCT05379985"}],"tags":["ctgov-ingest"],"related":[],"cancers":["nsclc","sclc","colorectal","pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":["daraxonrasib"],"companies":["revolution-medicines"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05379985","phase":"1/2","setting":"A Multicenter Open-Label Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS","sponsor":"Revolution Medicines, Inc.","enrolled":754,"outcomes":[]},"route":"/trials/nct05379985/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"drug":[{"id":"daraxonrasib","kind":"drug","name":"Daraxonrasib","route":"/drugs/daraxonrasib/"}],"company":[{"id":"revolution-medicines","kind":"company","name":"Revolution Medicines","route":"/companies/revolution-medicines/"}]}}