{"entity":{"id":"nct05382338","kind":"trial","name":"A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss","aka":[],"tldr":"A phase 3 trial of Cisplatin, Cyclophosphamide, Lomustine, Sodium thiosulfate and Vincristine in Medulloblastoma, run by Children's Oncology Group, now recruiting.","summary":"A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss is a phase 3 interventional study registered as NCT05382338 by Children's Oncology Group, with 225 participants planned, started 2023-02-20 and due to reach its primary completion in 2029-12-31. Interventions recorded: Audiometric Test, Auditory Brainstem Response, Biospecimen Collection, Cisplatin, Cyclophosphamide, Lomustine, Magnetic Resonance Imaging, Quality-of-Life Assessment, Radiation Therapy, Sodium Thiosulfate, Survey Administration, Vincristine. Conditions recorded: Childhood Medulloblastoma.\n\nLinked to the drug Sodium thiosulfate because the registry names it among its interventions and Medulloblastoma among its conditions. Registry record only: no result has been read by an editor.","status":"recruiting","asOf":"2026-09-22","links":[{"label":"ClinicalTrials.gov NCT05382338","url":"https://clinicaltrials.gov/study/NCT05382338"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["medulloblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":["cisplatin","cyclophosphamide","lomustine","sodium-thiosulfate","vincristine"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05382338","phase":"3","setting":"A Phase 3 Study of Sodium Thiosulfate for Reduction of Cisplatin-Induced Ototoxicity in Children With Average-Risk Medulloblastoma and Reduced Therapy in Children With Medulloblastoma With Low-Risk Features","sponsor":"Children's Oncology Group","enrolled":225,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05382338/","neighbours":{"cancer":[{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"}],"drug":[{"id":"cisplatin","kind":"drug","name":"Cisplatin","route":"/drugs/cisplatin/"},{"id":"cyclophosphamide","kind":"drug","name":"Cyclophosphamide","route":"/drugs/cyclophosphamide/"},{"id":"lomustine","kind":"drug","name":"Lomustine (CCNU)","route":"/drugs/lomustine/"},{"id":"sodium-thiosulfate","kind":"drug","name":"Sodium thiosulfate (otoprotectant)","route":"/drugs/sodium-thiosulfate/"},{"id":"vincristine","kind":"drug","name":"Vincristine","route":"/drugs/vincristine/"}]}}