{"entity":{"id":"nct05382442","kind":"trial","name":"A Study of AK112 With or Without AK117 in Metastatic Colorectal Cancer","aka":[],"tldr":"A phase 2 trial of Ivonescimab, AK117, CAPOX in colorectal cancer, run by Akeso, active and no longer recruiting.","summary":"A Study of AK112 With or Without AK117 in Metastatic Colorectal Cancer is a phase 2 interventional study registered as NCT05382442 by Akeso, with 254 participants planned, started 2022-06-27 and due to reach its primary completion in 2026-05-15. Interventions recorded: AK112, AK117, Oxaliplatin, Capecitabine, Irinotecan. Conditions listed: Metastatic Colorectal Cancer. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05382442","url":"https://clinicaltrials.gov/study/NCT05382442"}],"tags":["ctgov-ingest"],"related":[],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["ivonescimab","ak117","capox","capecitabine","folfiri","flot"],"companies":["akeso"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05382442","phase":"2","setting":"A Phase II Study of AK112 With or Without AK117 for Patients With Metastatic Colorectal Cancer","sponsor":"Akeso","enrolled":254,"outcomes":[]},"route":"/trials/nct05382442/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"drug":[{"id":"ak117","kind":"drug","name":"AK117","route":"/drugs/ak117/"},{"id":"capecitabine","kind":"drug","name":"Capecitabine","route":"/drugs/capecitabine/"},{"id":"capox","kind":"drug","name":"CAPOX (capecitabine, oxaliplatin)","route":"/drugs/capox/"},{"id":"flot","kind":"drug","name":"FLOT (5-FU, leucovorin, oxaliplatin, docetaxel)","route":"/drugs/flot/"},{"id":"folfiri","kind":"drug","name":"FOLFIRI (5-FU, leucovorin, irinotecan)","route":"/drugs/folfiri/"},{"id":"ivonescimab","kind":"drug","name":"Ivonescimab","route":"/drugs/ivonescimab/"}],"company":[{"id":"akeso","kind":"company","name":"Akeso","route":"/companies/akeso/"}]}}