{"entity":{"id":"nct05411718","kind":"trial","name":"A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome","aka":[],"tldr":"A phase 2 trial of aspirin in colorectal cancer, run by M.D. Anderson Cancer Center, now recruiting.","summary":"A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome is a phase 2, randomised interventional study registered as NCT05411718 by M.D. Anderson Cancer Center, with a registry enrolment figure of 40 participants, started 2023-03-21 and due to reach its primary completion in 2026-11-30. Interventions recorded: Naproxen; Aspirin. Conditions listed: T Cells; Colorectal Cancer; Lynch Syndrome. Primary outcome: To establish the effect of naproxen or aspirin on the abundance of T cells and other immune. Colorectal eligibility wording from the registry: \"* Participants must be at least 6 months from any prior cancer-directed treatment (such as surgical resection, chemotherapy, immunotherapy, hormonal therapy or radiation)\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05411718","url":"https://clinicaltrials.gov/study/NCT05411718"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer","msi-high-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["aspirin"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05411718","phase":"2","setting":"A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome","sponsor":"M.D. Anderson Cancer Center","enrolled":40,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05411718/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"drug":[{"id":"aspirin","kind":"drug","name":"Aspirin","route":"/drugs/aspirin/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}