{"entity":{"id":"nct05428969","kind":"trial","name":"A Study to Assess Safety, Tolerability and Preliminary Efficacy of Bexmarilimab in Combination With Standard of Care in Patients With Hematological Malignancies","aka":[],"tldr":"A phase 1/2 trial of Azacitidine and Venetoclax in acute myeloid leukaemia, chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms and myelodysplastic syndromes / neoplasms, run by Faron Pharmaceuticals Ltd, active and no longer recruiting.","summary":"A Study to Assess Safety, Tolerability and Preliminary Efficacy of Bexmarilimab in Combination With Standard of Care in Patients With Hematological Malignancies is a phase 1/2 interventional study registered as NCT05428969 by Faron Pharmaceuticals Ltd, with 181 participants enrolled, started 2022-06-02 and due to reach its primary completion in 2027-03. Interventions recorded: Bexmarilimab, Azacitidine and Venetoclax.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05428969","url":"https://clinicaltrials.gov/study/NCT05428969"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["aml","cmml","mds"],"sections":[],"technologies":[],"targets":[],"drugs":["azacitidine","venetoclax"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05428969","phase":"1/2","setting":"A Phase I/II Open-Label Study to Assess the Safety, Tolerability and Preliminary Efficacy of the Clever-1 Antibody Bexmarilimab in Combination With Standard of Care Therapy in Patients With Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia or Acute Myeloid Leukemia","sponsor":"Faron Pharmaceuticals Ltd","enrolled":181,"outcomes":[]},"route":"/trials/nct05428969/","neighbours":{"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"cmml","kind":"cancer","name":"Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms","route":"/cancers/cmml/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"}],"drug":[{"id":"azacitidine","kind":"drug","name":"Azacitidine","route":"/drugs/azacitidine/"},{"id":"bexmarilimab","kind":"drug","name":"Bexmarilimab","route":"/drugs/bexmarilimab/"},{"id":"venetoclax","kind":"drug","name":"Venetoclax","route":"/drugs/venetoclax/"}]}}