{"entity":{"id":"nct05445791","kind":"trial","name":"Metformin Plus Tyrosine Kinase Inhibitors for Treatment of Patients With Non-small Cell Lung Cancer With EGFR Mutations","aka":["METLUNG"],"tldr":"A phase 3 trial in lung cancer, run by Instituto Nacional de Cancerologia de Mexico, now recruiting.","summary":"Metformin Plus Tyrosine Kinase Inhibitors for Treatment of Patients With Non-small Cell Lung Cancer With EGFR Mutations is a phase 3, randomised interventional study registered as NCT05445791 by Instituto Nacional de Cancerologia de Mexico, with a registry enrolment figure of 312 participants, started 2021-07-15 and due to reach its primary completion in 2026-07-14. Interventions recorded: Metformin Hydrochloride; Placebo. Conditions listed: Non Small Cell Lung Cancer. Primary outcome: Progression-free survival. Lung eligibility wording from the registry: \"Patients with a histologically confirmed diagnosis of non-small cell lung cancer (stage IIIB-IV) according to the American Joint Committee on Cancer (AJCC) eight edition\". Sites: Mexico. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT05445791","url":"https://clinicaltrials.gov/study/NCT05445791"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["egfr-mutant-nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05445791","phase":"3","setting":"Effect of Metformin Plus Tyrosine Kinase Inhibitors Compared With Tyrosine Kinase Inhibitors Alone for Patients With Advanced Non-small Cell Lung Cancer and EGFR Mutations: Phase 3 Randomized Clinical Trial","sponsor":"Instituto Nacional de Cancerologia de Mexico","enrolled":312,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05445791/","neighbours":{"cancer":[{"id":"egfr-mutant-nsclc","kind":"cancer","name":"EGFR-mutated non-small-cell lung cancer","route":"/cancers/egfr-mutant-nsclc/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}