{"entity":{"id":"nct05450029","kind":"trial","name":"Neoadjuvant Chemoradiotherapy Plus Sintilimab for Intermediate/High Immunoscore Locally Advanced Rectal Cancer","aka":["SILAR"],"tldr":"A phase 2 trial of sintilimab in colorectal cancer, run by Yanhong Deng, now recruiting.","summary":"Neoadjuvant Chemoradiotherapy Plus Sintilimab for Intermediate/High Immunoscore Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT05450029 by Yanhong Deng, with a registry enrolment figure of 51 participants, started 2022-01-01 and due to reach its primary completion in 2024-01-01. Interventions recorded: Sintilimab. Conditions listed: Rectal Cancer. Primary outcome: Pathological complete response. Colorectal eligibility wording from the registry: \"Treatment-naive patients with histological or cytological documentation of rectal adenocarcinoma (\\<12 cm from the anal verge)\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05450029","url":"https://clinicaltrials.gov/study/NCT05450029"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["checkpoint-inhibitor","imrt-igrt"],"targets":[],"drugs":["sintilimab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05450029","phase":"2","setting":"Neoadjuvant Chemoradiotherapy Plus Sintilimab for Intermediate/High Immunoscore Locally Advanced Rectal Cancer: A Single-Center, Open-Label, Single-Arm, Phase 2 Trial","sponsor":"Yanhong Deng","enrolled":51,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05450029/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"drug":[{"id":"sintilimab","kind":"drug","name":"Sintilimab","route":"/drugs/sintilimab/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}