{"entity":{"id":"nct05450965","kind":"trial","name":"Study of PLK1 Inhibitor, Onvansertib, in Relapsed Small Cell Lung Cancer","aka":[],"tldr":"A phase 2 trial of onvansertib in lung cancer, run by University of Maryland, Baltimore, now recruiting.","summary":"Study of PLK1 Inhibitor, Onvansertib, in Relapsed Small Cell Lung Cancer is a phase 2, interventional study registered as NCT05450965 by University of Maryland, Baltimore, with a registry enrolment figure of 37 participants, started 2022-07-19 and due to reach its primary completion in 2027-08-31. Interventions recorded: Onvansertib. Conditions listed: Small-cell Lung Cancer; Small Cell Lung Carcinoma. Primary outcome: Objective Response Rate (ORR). Lung eligibility wording from the registry: \"Patients must have histologically or cytologically confirmed small cell lung cancer\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT05450965","url":"https://clinicaltrials.gov/study/NCT05450965"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["extensive-stage-sclc"],"sections":[],"technologies":[],"targets":[],"drugs":["onvansertib"],"companies":["cardiff-oncology"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05450965","phase":"2","setting":"A Phase 2 Study of PLK1 Inhibitor, Onvansertib, in Relapsed Small Cell Lung Cancer","sponsor":"University of Maryland, Baltimore","enrolled":37,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05450965/","neighbours":{"cancer":[{"id":"extensive-stage-sclc","kind":"cancer","name":"Extensive-stage small-cell lung cancer","route":"/cancers/extensive-stage-sclc/"}],"drug":[{"id":"onvansertib","kind":"drug","name":"Onvansertib","route":"/drugs/onvansertib/"}],"company":[{"id":"cardiff-oncology","kind":"company","name":"Cardiff Oncology","route":"/companies/cardiff-oncology/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}