{"entity":{"id":"nct05451784","kind":"trial","name":"Treatment of Advanced or Metastatic Triple-negative Breast Cancer With Adoptive Therapy of PD1+ TILS","aka":["TILS001"],"tldr":"A phase 1/2 trial in triple-negative breast cancer, run by Fundacio Clinic Barcelona, now recruiting.","summary":"Treatment of Advanced or Metastatic Triple-negative Breast Cancer With Adoptive Therapy of PD1+ TILS is a phase 1/2, interventional study registered as NCT05451784 by Fundacio Clinic Barcelona, with a registry enrolment figure of 20 participants, started 2022-07-20 and due to reach its primary completion in 2025-11-30. Interventions recorded: PD1+ TILs (NUMARZU-001) product infusion. Conditions listed: Metastatic Triple-Negative Breast Carcinoma. Triple-negative eligibility wording from the registry: \"Histologically confirmed diagnosis of advanced triple-negative breast cancer (based on the most recently analyzed biopsy from locally recurrent or metastatic site, local laboratory) meeting the following criteria: HER2-negative in situ hybridization test or an immunohistochemistry (IHC) status of 0 \". Sites: Spain. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05451784","url":"https://clinicaltrials.gov/study/NCT05451784"}],"tags":["ctgov-ingest","tnbc-deep-dive"],"related":[],"cancers":["tnbc-metastatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05451784","phase":"1/2","setting":"Treatment of Advanced or Metastatic Triple-negative Breast Cancer With Adoptive Therapy of PD1+ Tumor-infiltrating Lymphocytes (TILS001 Trial)","sponsor":"Fundacio Clinic Barcelona","enrolled":20,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05451784/","neighbours":{"cancer":[{"id":"tnbc-metastatic","kind":"cancer","name":"Metastatic triple-negative breast cancer","route":"/cancers/tnbc-metastatic/"}],"term":[{"id":"tnbc-trials-open-today","kind":"term","name":"Triple-negative breast cancer trials open today (registry snapshot and UK sites)","route":"/terms/tnbc-trials-open-today/"}]}}