{"entity":{"id":"nct05470283","kind":"trial","name":"Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanoma","aka":[],"tldr":"A phase 1 trial of Amsokigene autoleucel run by M.D. Anderson Cancer Center, active and no longer recruiting.","summary":"Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanoma is a phase 1 interventional study registered as NCT05470283 by M.D. Anderson Cancer Center, with 21 participants planned, started 2022-09-07. Conditions recorded: Tumor, Metastatic Melanoma and Melanoma. Interventions recorded: OBX-115, Acetazolamide, Cyclophosphamide, Furosemide, Mesna and Fludarabine Phosphate.","status":"active","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT05470283","url":"https://clinicaltrials.gov/study/NCT05470283"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer","advanced-melanoma","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":["amsokigene-autoleucel"],"companies":["obsidian-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05470283","phase":"1","setting":"Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanoma","sponsor":"M.D. Anderson Cancer Center","enrolled":21,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05470283/","neighbours":{"cancer":[{"id":"advanced-melanoma","kind":"cancer","name":"Advanced melanoma (unresectable stage III and stage IV)","route":"/cancers/advanced-melanoma/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"drug":[{"id":"amsokigene-autoleucel","kind":"drug","name":"Amsokigene autoleucel","route":"/drugs/amsokigene-autoleucel/"}],"company":[{"id":"obsidian-therapeutics","kind":"company","name":"Obsidian Therapeutics","route":"/companies/obsidian-therapeutics/"}]}}