{"entity":{"id":"nct05484024","kind":"trial","name":"Short-course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for Locally Advanced Rectal Cancer","aka":[],"tldr":"A phase 2/3 trial of sintilimab in colorectal cancer, run by Chinese Academy of Medical Sciences, not yet recruiting.","summary":"Short-course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for Locally Advanced Rectal Cancer is a phase 2/3, randomised interventional study registered as NCT05484024 by Chinese Academy of Medical Sciences, with a registry enrolment figure of 588 participants, started 2022-08-06 and due to reach its primary completion in 2028-07-31. Interventions recorded: Sintilimab; Short-course radiotherapy; CAPOX/mFOLFOX. Conditions listed: Rectal Neoplasms Malignant; Radiotherapy. Primary outcome: complete remission; Disease-free survival rate. Colorectal eligibility wording from the registry: \"* Biopsy proven rectal adenocarcinoma;\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05484024","url":"https://clinicaltrials.gov/study/NCT05484024"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["checkpoint-inhibitor","imrt-igrt"],"targets":[],"drugs":["sintilimab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05484024","phase":"2/3","setting":"Preoperative Short-course Radiotherapy Followed by Chemotherapy With or Without PD-1 Inhibitor for Locally Advanced Rectal Cancer: a Prospective, Multicenter, Randomized Controlled, Phase II/III Study (STELLAR II Study)","sponsor":"Chinese Academy of Medical Sciences","enrolled":588,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05484024/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"drug":[{"id":"sintilimab","kind":"drug","name":"Sintilimab","route":"/drugs/sintilimab/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}