{"entity":{"id":"nct05491083","kind":"trial","name":"Pembrolizumab and ADG106 in Advanced Solid Cancers and Triple Negative Breast Cancer","aka":["ComPACT"],"tldr":"A phase 1/2 trial in triple-negative breast cancer, run by National University Hospital, Singapore, now recruiting.","summary":"Pembrolizumab and ADG106 in Advanced Solid Cancers and Triple Negative Breast Cancer is a phase 1/2, interventional study registered as NCT05491083 by National University Hospital, Singapore, with a registry enrolment figure of 51 participants, started 2023-06-12 and due to reach its primary completion in 2026-12-31. Interventions recorded: Pembrolizumab & ADG106 (Phase Ib); Pembrolizumab & ADG106 (Phase II). Conditions listed: Advanced Solid Tumor; Triple Negative Breast Cancer. Triple-negative eligibility wording from the registry: \"* Patients with histologically or cytologically confirmed TNBC, defined by expression of estrogen (ER) and progesterone receptors (PR) of \\<1% and HER2 IHC score of 0 or 1+ or HER2 IHC score of 2+ but HER2 FISH negative\". Sites: Singapore. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05491083","url":"https://clinicaltrials.gov/study/NCT05491083"}],"tags":["ctgov-ingest","tnbc-deep-dive"],"related":[],"cancers":["tnbc-metastatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05491083","phase":"1/2","setting":"A Phase 1b Followed by Phase II Expansion Trial of Combination of Pembrolizumab and ADG106 in Advanced Solid Cancers and Triple Negative Breast Cancer (ComPACT)","sponsor":"National University Hospital, Singapore","enrolled":51,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05491083/","neighbours":{"cancer":[{"id":"tnbc-metastatic","kind":"cancer","name":"Metastatic triple-negative breast cancer","route":"/cancers/tnbc-metastatic/"}],"term":[{"id":"tnbc-trials-open-today","kind":"term","name":"Triple-negative breast cancer trials open today (registry snapshot and UK sites)","route":"/terms/tnbc-trials-open-today/"}]}}