{"entity":{"id":"nct05592626","kind":"trial","name":"A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors","aka":[],"tldr":"A phase 1/2 trial of FOLFIRI, Irinotecan, Docetaxel in non-small-cell lung cancer and small-cell lung cancer, run by Marengo Therapeutics, Inc., now recruiting.","summary":"A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors is a phase 1/2 interventional study registered as NCT05592626 by Marengo Therapeutics, Inc., with 366 participants planned, started 2023-01-04 and due to reach its primary completion in 2027-09. Interventions recorded: STAR0602, Irinotecan (Camptosar), Docetaxel (Taxotere). Conditions listed: Advanced Solid Tumors, Genital Neoplasm, Female, Urogenital Neoplasms, Lung Neoplasm. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05592626","url":"https://clinicaltrials.gov/study/NCT05592626"}],"tags":["ctgov-ingest"],"related":[],"cancers":["nsclc","sclc","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["folfiri","irinotecan","docetaxel"],"companies":["marengo-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05592626","phase":"1/2","setting":"A Phase 1/2, First-in-Human, Open-Label, Dose Escalation and Expansion Study of STAR0602, a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule, in Subjects With Unresectable, Locally Advanced, or Metastatic Solid Tumors That Are Antigen-rich (START-001)","sponsor":"Marengo Therapeutics, Inc.","enrolled":366,"outcomes":[]},"route":"/trials/nct05592626/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"drug":[{"id":"docetaxel","kind":"drug","name":"Docetaxel","route":"/drugs/docetaxel/"},{"id":"folfiri","kind":"drug","name":"FOLFIRI (5-FU, leucovorin, irinotecan)","route":"/drugs/folfiri/"},{"id":"irinotecan","kind":"drug","name":"Irinotecan (and liposomal irinotecan)","route":"/drugs/irinotecan/"}],"company":[{"id":"marengo-therapeutics","kind":"company","name":"Marengo Therapeutics","route":"/companies/marengo-therapeutics/"}]}}