{"entity":{"id":"nct05601440","kind":"trial","name":"Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer","aka":[],"tldr":"A phase 2 trial of Lunresertib run by Canadian Cancer Trials Group, now recruiting.","summary":"Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer is a phase 2 interventional study registered as NCT05601440 by Canadian Cancer Trials Group, with 484 participants planned, started 2023-06-13. Conditions recorded: Breast Cancer. Interventions recorded: RP-6306, Gemcitabine, Observation, Niraparib, Fulvestrant, RP-3500, CFI-402257, CFI-400945 and Sacituzumab govitecan.","status":"recruiting","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT05601440","url":"https://clinicaltrials.gov/study/NCT05601440"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["lunresertib","cfi-400945","cfi-402257"],"companies":["repare-therapeutics","debiopharm"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05601440","phase":"2","setting":"A Liquid-biopsy Informed Platform Trial to Evaluate Treatment in CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer","sponsor":"Canadian Cancer Trials Group","enrolled":484,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05601440/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}],"drug":[{"id":"cfi-400945","kind":"drug","name":"CFI-400945","route":"/drugs/cfi-400945/"},{"id":"cfi-402257","kind":"drug","name":"CFI-402257","route":"/drugs/cfi-402257/"},{"id":"lunresertib","kind":"drug","name":"Lunresertib","route":"/drugs/lunresertib/"}],"company":[{"id":"debiopharm","kind":"company","name":"Debiopharm","route":"/companies/debiopharm/"},{"id":"repare-therapeutics","kind":"company","name":"Repare Therapeutics","route":"/companies/repare-therapeutics/"}]}}