{"entity":{"id":"nct05601505","kind":"trial","name":"Circulating Tumor DNA-guided Neoadjuvant Treatment Strategy for Locally Advanced Rectal Cancer","aka":["CINTS-R"],"tldr":"A phase 2 trial in colorectal cancer, run by Peking Union Medical College Hospital, now recruiting.","summary":"Circulating Tumor DNA-guided Neoadjuvant Treatment Strategy for Locally Advanced Rectal Cancer is a phase 2, randomised interventional study registered as NCT05601505 by Peking Union Medical College Hospital, with a registry enrolment figure of 470 participants, started 2023-02-03 and due to reach its primary completion in 2025-10-31. Interventions recorded: circulating tumor DNA. Conditions listed: Locally Advanced Rectal Carcinoma; Circulating Tumor DNA. Primary outcome: two-year disease-related treatment failure, 2y-DrTF. Colorectal eligibility wording from the registry: \"Rectal adenocarcinoma confirmed by pathology;\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05601505","url":"https://clinicaltrials.gov/study/NCT05601505"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["mrd-testing"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05601505","phase":"2","setting":"Circulating Tumor DNA-guided Neoadjuvant Treatment Strategy for Locally Advanced Rectal Cancer --- a Multicenter Randomized Controlled Trial (CINTS-R)","sponsor":"Peking Union Medical College Hospital","enrolled":470,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05601505/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"mrd-testing","kind":"technology","name":"MRD / molecular residual disease testing","route":"/technologies/mrd-testing/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}