{"entity":{"id":"nct05609578","kind":"trial","name":"Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation","aka":[],"tldr":"A phase 2 trial of Adagrasib, Pembrolizumab, Pemetrexed, Carboplatin and Cisplatin in non-small-cell lung cancer, run by Mirati Therapeutics Inc., active and no longer recruiting.","summary":"Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation is a phase 2 interventional study registered as NCT05609578 by Mirati Therapeutics Inc., with 90 participants enrolled, started 2022-11-22 and due to reach its primary completion in 2026-09-30. Interventions recorded: Adagrasib oral dose of 400 mg twice daily tablets, Pembrolizumab, Chemotherapy: Pemetrexed and Cisplatin/Carboplatin.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05609578","url":"https://clinicaltrials.gov/study/NCT05609578"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":["adagrasib","pembrolizumab","pemetrexed","carboplatin","cisplatin"],"companies":["bms"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05609578","phase":"2","setting":"A Phase 2 Trial of Combination Therapies With Adagrasib in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation","sponsor":"Mirati Therapeutics Inc.","enrolled":90,"outcomes":[]},"route":"/trials/nct05609578/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"drug":[{"id":"adagrasib","kind":"drug","name":"Adagrasib","route":"/drugs/adagrasib/"},{"id":"carboplatin","kind":"drug","name":"Carboplatin","route":"/drugs/carboplatin/"},{"id":"cisplatin","kind":"drug","name":"Cisplatin","route":"/drugs/cisplatin/"},{"id":"pembrolizumab","kind":"drug","name":"Pembrolizumab","route":"/drugs/pembrolizumab/"},{"id":"pemetrexed","kind":"drug","name":"Pemetrexed","route":"/drugs/pemetrexed/"}],"company":[{"id":"bms","kind":"company","name":"Bristol Myers Squibb","route":"/companies/bms/"}]}}