{"entity":{"id":"nct05650879","kind":"trial","name":"ELVN-002 in HER2 Mutant Non-Small Cell Lung Cancer","aka":[],"tldr":"A phase 1 trial of ELVN-002 run by Enliven Therapeutics, active and no longer recruiting.","summary":"ELVN-002 in HER2 Mutant Non-Small Cell Lung Cancer is a phase 1 interventional study registered as NCT05650879 by Enliven Therapeutics, with 198 participants planned, started 2023-03-20. Conditions recorded: HER2 Mutant Non-small Cell Lung Cancer, HER2-positive Metastatic Breast Cancer, HER2 Gene Mutation and HER2 Amplification. Interventions recorded: ELVN-002, Fam-Trastuzumab Deruxtecan-Nxki and Trastuzumab emtansine.","status":"active","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT05650879","url":"https://clinicaltrials.gov/study/NCT05650879"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["her2-mutant-nsclc","breast-her2-positive","metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["elvn-002"],"companies":["enliven-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05650879","phase":"1","setting":"A Phase 1a/1b Study of ELVN-002 for the Treatment of Patients With HER2 Mutant Non-Small Cell Lung Cancer","sponsor":"Enliven Therapeutics","enrolled":198,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05650879/","neighbours":{"cancer":[{"id":"her2-mutant-nsclc","kind":"cancer","name":"HER2-mutant non-small-cell lung cancer","route":"/cancers/her2-mutant-nsclc/"},{"id":"breast-her2-positive","kind":"cancer","name":"HER2-positive breast cancer","route":"/cancers/breast-her2-positive/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"drug":[{"id":"elvn-002","kind":"drug","name":"ELVN-002","route":"/drugs/elvn-002/"}],"company":[{"id":"enliven-therapeutics","kind":"company","name":"Enliven Therapeutics","route":"/companies/enliven-therapeutics/"}]}}