{"entity":{"id":"nct05692024","kind":"trial","name":"COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER","aka":["COMMENCER"],"tldr":"A phase 1/2 trial in colorectal cancer, run by Massachusetts General Hospital, now recruiting.","summary":"COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER is a phase 1/2, randomised interventional study registered as NCT05692024 by Massachusetts General Hospital, with a registry enrolment figure of 80 participants, started 2024-03-21 and due to reach its primary completion in 2028-03-31. Interventions recorded: Nestlé NESCAFÉ® TASTER'S CHOICE® House Blend capsule.; Placebo. Conditions listed: Colorectal Cancer; Coffee; Gastrointestinal Microbiome; Stenosis; Fibrosis, Liver; Ultrasound Elastography; Proton Magnetic Resonance Spectroscopy. Primary outcome: Change in hepatic fat fraction.. Colorectal eligibility wording from the registry: \"* Participants must have histologically confirmed stage I, II, or III colon or rectal adenocarcinoma and have completed standard treatment (including surgery, chemotherapy and radiotherapy) at least 2 months ago\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05692024","url":"https://clinicaltrials.gov/study/NCT05692024"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05692024","phase":"1/2","setting":"COMMENCER: COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER","sponsor":"Massachusetts General Hospital","enrolled":80,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05692024/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}