{"entity":{"id":"nct05732389","kind":"trial","name":"Immunotherapy in Patients With Early dMMR Rectal Cancer","aka":["RESET-R"],"tldr":"A phase 2 trial of nivolumab and ipilimumab in colorectal cancer, run by Odense University Hospital, now recruiting.","summary":"Immunotherapy in Patients With Early dMMR Rectal Cancer is a phase 2, interventional study registered as NCT05732389 by Odense University Hospital, with a registry enrolment figure of 39 participants, started 2023-02-01 and due to reach its primary completion in 2027-07. Interventions recorded: Nivolumab; Ipilimumab. Conditions listed: Cancer of Rectum. Primary outcome: Complete clinical response. Colorectal eligibility wording from the registry: \"* Histologically verified non-metastatic rectal cancer stage 1-3\". Sites: Denmark. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05732389","url":"https://clinicaltrials.gov/study/NCT05732389"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","msi-high-colorectal"],"sections":[],"technologies":["checkpoint-inhibitor"],"targets":[],"drugs":["nivolumab","ipilimumab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05732389","phase":"2","setting":"Immunotherapy in Patients With Early dMMR Rectal Cancer","sponsor":"Odense University Hospital","enrolled":39,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05732389/","neighbours":{"cancer":[{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"}],"drug":[{"id":"ipilimumab","kind":"drug","name":"Ipilimumab","route":"/drugs/ipilimumab/"},{"id":"nivolumab","kind":"drug","name":"Nivolumab","route":"/drugs/nivolumab/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}