{"entity":{"id":"nct05745740","kind":"trial","name":"A Study of RC48-ADC Combined With Pyrotinib For Treatment of Local Advanced or Metastasis NSCLC With HER2 Mutation","aka":[],"tldr":"A phase 1/2 trial of pyrotinib in lung cancer, run by RemeGen Co., Ltd., not yet recruiting.","summary":"A Study of RC48-ADC Combined With Pyrotinib For Treatment of Local Advanced or Metastasis NSCLC With HER2 Mutation is a phase 1/2, interventional study registered as NCT05745740 by RemeGen Co., Ltd., with a registry enrolment figure of 26 participants, started 2027-12-01 and due to reach its primary completion in 2027-12-01. Interventions recorded: RC48-ADC; Pyrotinib. Conditions listed: Non-small Cell Lung Cancer. Primary outcome: maximal tolerance dose (MTD) of RC48-ADC combined with Pyrotinib. Lung eligibility wording from the registry: \"* According to UICC/AJCC 8th Edition, histologically and/or cytologically-confirmed, cannot be surgically removed, locally advanced or metastatic NSCLC\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT05745740","url":"https://clinicaltrials.gov/study/NCT05745740"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["her2-mutant-nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":["pyrotinib"],"companies":["remegen"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05745740","phase":"1/2","setting":"An Open-label, Single-center, Phase Ib/II Study to Evaluate the Safety, Efficacy and Pharmacokinetics of RC48-ADC Combined With Pyrotinib in Local Advanced or Metastasis NSCLC With HER2 Mutation","sponsor":"RemeGen Co., Ltd.","enrolled":26,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05745740/","neighbours":{"cancer":[{"id":"her2-mutant-nsclc","kind":"cancer","name":"HER2-mutant non-small-cell lung cancer","route":"/cancers/her2-mutant-nsclc/"}],"drug":[{"id":"pyrotinib","kind":"drug","name":"Pyrotinib","route":"/drugs/pyrotinib/"}],"company":[{"id":"remegen","kind":"company","name":"RemeGen","route":"/companies/remegen/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}