{"entity":{"id":"nct05752136","kind":"trial","name":"Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma","aka":[],"tldr":"A phase 3 trial of envafolimab in colorectal cancer, run by Sir Run Run Shaw Hospital, now recruiting.","summary":"Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma is a phase 3, randomised interventional study registered as NCT05752136 by Sir Run Run Shaw Hospital, with a registry enrolment figure of 108 participants, started 2023-04-01 and due to reach its primary completion in 2026-11-01. Interventions recorded: Envafolimab. Conditions listed: Rectal Cancer. Primary outcome: pCR rate. Colorectal eligibility wording from the registry: \"Diagnosed by digital rectal examination, colonoscopy, and high-resolution MRI of the pelvis, the tumor is less than or equal to 12 cm from the anus\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05752136","url":"https://clinicaltrials.gov/study/NCT05752136"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["checkpoint-inhibitor"],"targets":[],"drugs":["envafolimab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05752136","phase":"3","setting":"Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma: a Prospective, Multicenter, Randomized Controlled Study (PRECAM-R)","sponsor":"Sir Run Run Shaw Hospital","enrolled":108,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05752136/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"}],"drug":[{"id":"envafolimab","kind":"drug","name":"Envafolimab","route":"/drugs/envafolimab/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}