{"entity":{"id":"nct05784688","kind":"trial","name":"Study of TU2218 in Combination With KEYTRUDA®(Pembrolizumab) in Patients With Advanced Solid Tumors","aka":[],"tldr":"A phase 1/2 trial of Pembrolizumab in head and neck squamous cell carcinoma and colorectal cancer, run by TiumBio Co., Ltd., now recruiting.","summary":"Study of TU2218 in Combination With KEYTRUDA®(Pembrolizumab) in Patients With Advanced Solid Tumors is a phase 1/2 interventional study registered as NCT05784688 by TiumBio Co., Ltd., with 140 participants planned, started 2023-03-10 and due to reach its primary completion in 2026-12. Interventions recorded: TU2218 + KEYTRUDA® (Pembrolizumab). Conditions listed: Solid Tumor, Biliary Tract Cancer, Head and Neck Squamous Cell Carcinoma, Colorectal Cancer. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05784688","url":"https://clinicaltrials.gov/study/NCT05784688"}],"tags":["ctgov-ingest"],"related":[],"cancers":["head-and-neck","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["pembrolizumab"],"companies":["tiumbio"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05784688","phase":"1/2","setting":"A Phase 1b/2a Study to Assess the Safety, Pharmacokinetics, and Preliminary Efficacy of TU2218, an Oral TGFβR Serine/Threonine Kinase Inhibitor, Administered in Combination With Pembrolizumab in Patients With Advanced Solid Tumors","sponsor":"TiumBio Co., Ltd.","enrolled":140,"outcomes":[]},"route":"/trials/nct05784688/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"}],"drug":[{"id":"pembrolizumab","kind":"drug","name":"Pembrolizumab","route":"/drugs/pembrolizumab/"}],"company":[{"id":"tiumbio","kind":"company","name":"TiumBio","route":"/companies/tiumbio/"}]}}