{"entity":{"id":"nct05800223","kind":"trial","name":"Armatinib Alone or in Combination With SRT for Brain Metastases EGFR-mutated Non-small Cell Lung Cancer","aka":[],"tldr":"A phase 3 trial of aumolertinib in lung cancer, run by Shanghai Cancer Hospital, China, now recruiting.","summary":"Armatinib Alone or in Combination With SRT for Brain Metastases EGFR-mutated Non-small Cell Lung Cancer is a phase 3, randomised interventional study registered as NCT05800223 by Shanghai Cancer Hospital, China, with a registry enrolment figure of 300 participants, started 2023-01-01 and due to reach its primary completion in 2027-12. Interventions recorded: Almonertinib; SBRT. Conditions listed: Non-small Cell Lung Cancer Metastatic. Primary outcome: iPFS. Lung eligibility wording from the registry: \"histologically confirmed NSCLC (by AJCC 8th edition lung cancer staging criteria)\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT05800223","url":"https://clinicaltrials.gov/study/NCT05800223"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["egfr-mutant-nsclc"],"sections":[],"technologies":["kinase-inhibitors","sbrt"],"targets":[],"drugs":["aumolertinib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05800223","phase":"3","setting":"Prospective, Multicenter, Randomized Controlled, Phase III Clinical Study of Armatinib Alone or in Combination With Stereotactic Body Radiotherapy (SRT) for First-line Treatment of Brain Metastases From EGFR-mutated Non-small Cell Lung Cancer","sponsor":"Shanghai Cancer Hospital, China","enrolled":300,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05800223/","neighbours":{"cancer":[{"id":"egfr-mutant-nsclc","kind":"cancer","name":"EGFR-mutated non-small-cell lung cancer","route":"/cancers/egfr-mutant-nsclc/"}],"technology":[{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"},{"id":"kinase-inhibitors","kind":"technology","name":"Small-molecule kinase inhibitors","route":"/technologies/kinase-inhibitors/"}],"drug":[{"id":"aumolertinib","kind":"drug","name":"Aumolertinib","route":"/drugs/aumolertinib/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}