{"entity":{"id":"nct05821556","kind":"trial","name":"Valproic Acid/Simvastatin Plus Gemcitabine/Nab-paclitaxel Based Regimens in Untreated Metastatic Pancreatic Adenocarcinoma Patients","aka":[],"tldr":"A phase 2 trial of nab-paclitaxel, cisplatin and capecitabine in pancreatic cancer, run by National Cancer Institute, Naples, now recruiting.","summary":"Valproic Acid/Simvastatin Plus Gemcitabine/Nab-paclitaxel Based Regimens in Untreated Metastatic Pancreatic Adenocarcinoma Patients is a phase 2, randomised interventional study registered as NCT05821556 by National Cancer Institute, Naples, with a registry enrolment figure of 240 participants, started 2023-06-12 and due to reach its primary completion in 2026-08. Interventions recorded: Valproic acid; Simvastatin 20mg; Gemcitabine 1000 mg; Nab paclitaxel; Cisplatin; Capecitabine. Conditions listed: Adenocarcinoma of the Pancreas. Primary outcome: Progression Free Survival (PFS). Sites: Italy, Spain. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05821556","url":"https://clinicaltrials.gov/study/NCT05821556"}],"tags":["ctgov-ingest","pancreatic-deep-dive"],"related":[],"cancers":["metastatic-pdac"],"sections":[],"technologies":["cytotoxic-chemotherapy","platinum"],"targets":[],"drugs":["nab-paclitaxel","cisplatin","capecitabine"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05821556","phase":"2","setting":"Randomized Phase 2 Study of Valproic Acid combinEd With Simvastatin and Gemcitabine/Nab-paclitaxel-based Regimens in Untreated Metastatic Pancreatic Adenocarcinoma Patients (The VESPA Trial).","sponsor":"National Cancer Institute, Naples","enrolled":240,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05821556/","neighbours":{"cancer":[{"id":"metastatic-pdac","kind":"cancer","name":"Metastatic pancreatic ductal adenocarcinoma","route":"/cancers/metastatic-pdac/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"platinum","kind":"technology","name":"Platinum agents","route":"/technologies/platinum/"}],"drug":[{"id":"capecitabine","kind":"drug","name":"Capecitabine","route":"/drugs/capecitabine/"},{"id":"cisplatin","kind":"drug","name":"Cisplatin","route":"/drugs/cisplatin/"},{"id":"nab-paclitaxel","kind":"drug","name":"Nab-paclitaxel","route":"/drugs/nab-paclitaxel/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}