{"entity":{"id":"nct05840016","kind":"trial","name":"AK112 in Combination With Chemotherapy in Advanced Squamous Non-Small Cell Lung Cancer","aka":[],"tldr":"A phase 3 trial of Ivonescimab, Carboplatin, Tislelizumab in non-small-cell lung cancer and small-cell lung cancer, run by Akeso, active and no longer recruiting.","summary":"AK112 in Combination With Chemotherapy in Advanced Squamous Non-Small Cell Lung Cancer is a phase 3 interventional study registered as NCT05840016 by Akeso, with 532 participants enrolled, started 2023-08-17 and due to reach its primary completion in 2025-02-28. Interventions recorded: AK112, Carboplatin, Paxlitaxel, Tislelizumab, Carboplatin, Paxlitaxel. Conditions listed: Advanced Squamous Non Small Cell Lung Cancer. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05840016","url":"https://clinicaltrials.gov/study/NCT05840016"}],"tags":["ctgov-ingest"],"related":[],"cancers":["nsclc","sclc"],"sections":[],"technologies":[],"targets":[],"drugs":["ivonescimab","carboplatin","tislelizumab"],"companies":["akeso"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05840016","phase":"3","setting":"A Randomized, Controlled, Multi-center Phase III Clinical Study of AK112 Combined With Chemotherapy Versus PD-1 Inhibitor Combined With Chemotherapy as First-line Treatment for Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer","sponsor":"Akeso","enrolled":532,"outcomes":[]},"route":"/trials/nct05840016/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"drug":[{"id":"carboplatin","kind":"drug","name":"Carboplatin","route":"/drugs/carboplatin/"},{"id":"ivonescimab","kind":"drug","name":"Ivonescimab","route":"/drugs/ivonescimab/"},{"id":"tislelizumab","kind":"drug","name":"Tislelizumab","route":"/drugs/tislelizumab/"}],"company":[{"id":"akeso","kind":"company","name":"Akeso","route":"/companies/akeso/"}]}}