{"entity":{"id":"nct05846789","kind":"trial","name":"Toci +/- SOC Chemo for Metastatic Triple Negative and ER-positive, HER2-negative Breast Cancers","aka":[],"tldr":"A phase 2 trial of tocilizumab in triple-negative breast cancer, run by Kathy Miller, now recruiting.","summary":"Toci +/- SOC Chemo for Metastatic Triple Negative and ER-positive, HER2-negative Breast Cancers is a phase 2, randomised interventional study registered as NCT05846789 by Kathy Miller, with a registry enrolment figure of 168 participants, started 2024-07-02 and due to reach its primary completion in 2027-12. Interventions recorded: SOC Chemotherapy; Tocilizumab/Tocilizumab Biosimilar. Conditions listed: Metastatic Breast Cancer; Triple Negative Breast Cancer; Estrogen-receptor-low Breast Cancer; ER Positive, HER2 Negative Breast Cancer. Triple-negative eligibility wording from the registry: \"Locally recurrent (not amenable to local therapy with curative intent) or metastatic breast cancer that is triple negative or ER-positive (ER and PR ≤ 1% weak staining)\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05846789","url":"https://clinicaltrials.gov/study/NCT05846789"}],"tags":["ctgov-ingest","tnbc-deep-dive"],"related":[],"cancers":["tnbc-metastatic"],"sections":[],"technologies":[],"targets":[],"drugs":["tocilizumab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05846789","phase":"2","setting":"A Pragmatic Phase II Trial of Chemotherapy +/- Tocilizumab for Metastatic Triple Negative and ER-positive, HER2-negative Breast Cancers","sponsor":"Kathy Miller","enrolled":168,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05846789/","neighbours":{"cancer":[{"id":"tnbc-metastatic","kind":"cancer","name":"Metastatic triple-negative breast cancer","route":"/cancers/tnbc-metastatic/"}],"drug":[{"id":"tocilizumab","kind":"drug","name":"Tocilizumab","route":"/drugs/tocilizumab/"}],"term":[{"id":"tnbc-trials-open-today","kind":"term","name":"Triple-negative breast cancer trials open today (registry snapshot and UK sites)","route":"/terms/tnbc-trials-open-today/"}]}}