{"entity":{"id":"nct05864534","kind":"trial","name":"Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma","aka":[],"tldr":"A phase 2 trial of Transcranial focused ultrasound systems in Glioma & glioblastoma, run by Northwestern University, now recruiting.","summary":"Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma is a phase 2 interventional study registered as NCT05864534 by Northwestern University, with 25 participants planned, started 2024-01-19 and due to reach its primary completion in 2031-07-31. Interventions recorded: Balstilimab, Botensilimab, Liposomal Doxorubicin, Sonocloud-9 (SC-9). Conditions recorded: Newly Diagnosed Glioblastoma, Glioblastoma, Isocitric Dehydrogenase (IDH)-Wildtype, Gliosarcoma, Glioblastoma Multiforme.\n\nLinked to the technology Transcranial focused ultrasound systems because the registry names it (\"sonocloud\") among its interventions and Glioma & glioblastoma among its conditions. Registry record only: no result has been read by an editor.","status":"recruiting","asOf":"2026-09-22","links":[{"label":"ClinicalTrials.gov NCT05864534","url":"https://clinicaltrials.gov/study/NCT05864534"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["glioblastoma"],"sections":[],"technologies":["transcranial-focused-ultrasound-systems"],"targets":[],"drugs":["balstilimab","botensilimab","doxorubicin"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05864534","phase":"2","setting":"A Phase 2a Trial of Immune Modulation in Combination With Ultrasound-mediated Blood Brain Barrier Opening in Patients With Newly Diagnosed Glioblastoma","sponsor":"Northwestern University","enrolled":25,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05864534/","neighbours":{"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"technology":[{"id":"transcranial-focused-ultrasound-systems","kind":"technology","name":"Transcranial focused ultrasound systems (Exablate Neuro, SonoCloud)","route":"/technologies/transcranial-focused-ultrasound-systems/"}],"drug":[{"id":"balstilimab","kind":"drug","name":"Balstilimab","route":"/drugs/balstilimab/"},{"id":"botensilimab","kind":"drug","name":"Botensilimab","route":"/drugs/botensilimab/"},{"id":"doxorubicin","kind":"drug","name":"Doxorubicin","route":"/drugs/doxorubicin/"}]}}