{"entity":{"id":"nct05867251","kind":"trial","name":"Study of AVZO-021 in Patients With Advanced Solid Tumors","aka":[],"tldr":"A phase 1/2 trial of AVZO-021, Palbociclib, Fulvestrant in ovarian cancer and endometrial cancer, run by Avenzo Therapeutics, Inc., now recruiting.","summary":"Study of AVZO-021 in Patients With Advanced Solid Tumors is a phase 1/2 interventional study registered as NCT05867251 by Avenzo Therapeutics, Inc., with 430 participants planned, started 2023-08-30 and due to reach its primary completion in 2028-01-31. Interventions recorded: AVZO-021, Palbociclib, Fulvestrant, Letrozole, Ribociclib. Conditions listed: Advanced Solid Tumor, HR+/HER2- Breast Cancer, HR+, HER2-, Advanced Breast Cancer, CCNE1 Amplification. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05867251","url":"https://clinicaltrials.gov/study/NCT05867251"}],"tags":["ctgov-ingest"],"related":[],"cancers":["ovarian","endometrial"],"sections":[],"technologies":[],"targets":[],"drugs":["avzo-021","palbociclib","fulvestrant","letrozole","ribociclib","abemaciclib"],"companies":["avenzo"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05867251","phase":"1/2","setting":"A Phase 1/2, First-in-Human Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of AVZO-021 as a Single Agent and in Combination Therapy in Patients With Advanced Solid Tumors","sponsor":"Avenzo Therapeutics, Inc.","enrolled":430,"outcomes":[]},"route":"/trials/nct05867251/","neighbours":{"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"drug":[{"id":"abemaciclib","kind":"drug","name":"Abemaciclib","route":"/drugs/abemaciclib/"},{"id":"avzo-021","kind":"drug","name":"AVZO-021","route":"/drugs/avzo-021/"},{"id":"fulvestrant","kind":"drug","name":"Fulvestrant","route":"/drugs/fulvestrant/"},{"id":"letrozole","kind":"drug","name":"Letrozole (and other aromatase inhibitors)","route":"/drugs/letrozole/"},{"id":"palbociclib","kind":"drug","name":"Palbociclib","route":"/drugs/palbociclib/"},{"id":"ribociclib","kind":"drug","name":"Ribociclib","route":"/drugs/ribociclib/"}],"company":[{"id":"avenzo","kind":"company","name":"Avenzo Therapeutics","route":"/companies/avenzo/"}]}}