{"entity":{"id":"nct05902988","kind":"trial","name":"A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer","aka":[],"tldr":"A phase 1/2 trial of VLS-1488 in non-small-cell lung cancer, triple-negative breast cancer, head and neck squamous cell carcinoma, ovarian cancer, sarcomas and endometrial cancer, run by Volastra Therapeutics, Inc., now recruiting.","summary":"A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer is a phase 1/2 interventional study registered as NCT05902988 by Volastra Therapeutics, Inc., with 200 participants planned, started 2023-10-18 and due to reach its primary completion in 2026-06. Interventions recorded: VLS-1488.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05902988","url":"https://clinicaltrials.gov/study/NCT05902988"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["nsclc","tnbc","head-and-neck","ovarian","sarcoma","endometrial"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05902988","phase":"1/2","setting":"A Phase I/II Study of VLS-1488 (an Oral KIF18A Inhibitor) in Subjects With Advanced Cancer","sponsor":"Volastra Therapeutics, Inc.","enrolled":200,"outcomes":[]},"route":"/trials/nct05902988/","neighbours":{"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}]}}