{"entity":{"id":"nct05904379","kind":"trial","name":"AK112 and AK104 With or Without Chemotherapy in Advanced Non-small Cell Lung Cancer","aka":[],"tldr":"A phase 1/2 trial of Ivonescimab, Cadonilimab, Carboplatin in non-small-cell lung cancer and small-cell lung cancer, run by Akeso, active and no longer recruiting.","summary":"AK112 and AK104 With or Without Chemotherapy in Advanced Non-small Cell Lung Cancer is a phase 1/2 interventional study registered as NCT05904379 by Akeso, with 233 participants planned, started 2023-07-13 and due to reach its primary completion in 2026-06-30. Interventions recorded: AK112, AK104, Carboplatin, paclitaxel, pemetrexed. Conditions listed: Advanced Non-small-cell Lung Cancer. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05904379","url":"https://clinicaltrials.gov/study/NCT05904379"}],"tags":["ctgov-ingest"],"related":[],"cancers":["nsclc","sclc"],"sections":[],"technologies":[],"targets":[],"drugs":["ivonescimab","cadonilimab","carboplatin","paclitaxel","pemetrexed","docetaxel"],"companies":["akeso"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05904379","phase":"1/2","setting":"A Phase Ib/II Clinical Trial of AK112 and AK104 With or Without Chemotherapy in Advanced Non-small Cell Lung Cancer","sponsor":"Akeso","enrolled":233,"outcomes":[]},"route":"/trials/nct05904379/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"drug":[{"id":"cadonilimab","kind":"drug","name":"Cadonilimab","route":"/drugs/cadonilimab/"},{"id":"carboplatin","kind":"drug","name":"Carboplatin","route":"/drugs/carboplatin/"},{"id":"docetaxel","kind":"drug","name":"Docetaxel","route":"/drugs/docetaxel/"},{"id":"ivonescimab","kind":"drug","name":"Ivonescimab","route":"/drugs/ivonescimab/"},{"id":"paclitaxel","kind":"drug","name":"Paclitaxel / nab-paclitaxel","route":"/drugs/paclitaxel/"},{"id":"pemetrexed","kind":"drug","name":"Pemetrexed","route":"/drugs/pemetrexed/"}],"company":[{"id":"akeso","kind":"company","name":"Akeso","route":"/companies/akeso/"}]}}