{"entity":{"id":"nct05914389","kind":"trial","name":"Induction Chemotherapy Combined With Neoadjuvant Immunotherapy for MSS Colon Cancer","aka":["ICONIC"],"tldr":"A phase 2 trial of fOLFOX (5-FU, leucovorin, oxaliplatin) and capecitabine in colorectal cancer, run by Second Affiliated Hospital, Zhejiang University, School of Medicine, now recruiting.","summary":"Induction Chemotherapy Combined With Neoadjuvant Immunotherapy for MSS Colon Cancer is a phase 2, randomised interventional study registered as NCT05914389 by Second Affiliated Hospital, Zhejiang University, School of Medicine, with a registry enrolment figure of 100 participants, started 2023-08 and due to reach its primary completion in 2025-08. Interventions recorded: Oxaliplatin; Capecitabine; Anti-PD-L1 Monoclonal Antibody; Clostridium butyricum; Colectomy. Conditions listed: Colon Neoplasm. Primary outcome: TRG0/1. Colorectal eligibility wording from the registry: \"* Pathologically diagnosed MSS or pMMR-type colon adenocarcinoma\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05914389","url":"https://clinicaltrials.gov/study/NCT05914389"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["colon-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","platinum"],"targets":[],"drugs":["folfox","capecitabine"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05914389","phase":"2","setting":"Induction Chemotherapy Combined With Neoadjuvant Immunotherapy for MSS Colon Cancer: a Prospective Single-center Multi-arm Open-label Randomized Phase II Study","sponsor":"Second Affiliated Hospital, Zhejiang University, School of Medicine","enrolled":100,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05914389/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"platinum","kind":"technology","name":"Platinum agents","route":"/technologies/platinum/"}],"drug":[{"id":"capecitabine","kind":"drug","name":"Capecitabine","route":"/drugs/capecitabine/"},{"id":"folfox","kind":"drug","name":"FOLFOX (5-FU, leucovorin, oxaliplatin)","route":"/drugs/folfox/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}