{"entity":{"id":"nct05939661","kind":"trial","name":"A Multicenter Single-arm P2 to Evaluate Safety and Efficacy of the Total Neoadjuvant Therapy for cT2 Rectal Cancer","aka":["AMBITION"],"tldr":"A phase 2 trial in colorectal cancer, run by Osaka University, now recruiting.","summary":"A Multicenter Single-arm P2 to Evaluate Safety and Efficacy of the Total Neoadjuvant Therapy for cT2 Rectal Cancer is a phase 2, interventional study registered as NCT05939661 by Osaka University, with a registry enrolment figure of 45 participants, started 2023-05-25 and due to reach its primary completion in 2026-03-31. Interventions recorded: Radiation; Chemotherapy; Surgery. Conditions listed: Rectal Cancer. Primary outcome: Pathological complete response (pCR). Colorectal eligibility wording from the registry: \"The patient has adenocarcinoma of the rectum confirmed by histological examination\". Sites: Japan. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05939661","url":"https://clinicaltrials.gov/study/NCT05939661"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05939661","phase":"2","setting":"A Multicenter Single-arm Phase 2 Study to Evaluate Safety and Efficacy of the Total Neoadjuvant Therapy of Short Course Radiation Therapy Followed by Neoadjuvant Oxaliplatin/Fluorouracil-based Chemotherapy (CAPOX) for cT2 Rectal Cancer.","sponsor":"Osaka University","enrolled":45,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05939661/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}