{"entity":{"id":"nct05944224","kind":"trial","name":"A Study to Efficacy and Safety of SPH4336 Monotherapy or in Combination With Cadonilimab in Patients With Advanced Solid Tumors.","aka":[],"tldr":"A phase 1/2 trial of SPH4336 and Cadonilimab in advanced solid tumours, run by Shanghai Pharmaceuticals Holding Co., Ltd, now recruiting.","summary":"A Study to Efficacy and Safety of SPH4336 Monotherapy or in Combination With Cadonilimab in Patients With Advanced Solid Tumors. is a phase 1/2 interventional study registered as NCT05944224 by Shanghai Pharmaceuticals Holding Co., Ltd, with 63 participants planned, started 2023-10-17 and due to reach its primary completion in 2026-12-31. Interventions recorded: SPH4336 and Cadonilimab.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05944224","url":"https://clinicaltrials.gov/study/NCT05944224"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["sph4336","cadonilimab"],"companies":["genfleet"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05944224","phase":"1/2","setting":"A Randomized, Open-label, Phase Ib/IIa Clinical Study to Evaluate the Efficacy and Safety of SPH4336 Monotherapy or in Combination With Cadonilimab in Patients With Advanced Solid Tumors, Including Advanced Well Differentiated/Dedifferentiated Liposarcoma.","sponsor":"Shanghai Pharmaceuticals Holding Co., Ltd","enrolled":63,"outcomes":[]},"route":"/trials/nct05944224/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"drug":[{"id":"cadonilimab","kind":"drug","name":"Cadonilimab","route":"/drugs/cadonilimab/"},{"id":"sph4336","kind":"drug","name":"SPH4336","route":"/drugs/sph4336/"}],"company":[{"id":"genfleet","kind":"company","name":"GenFleet Therapeutics","route":"/companies/genfleet/"}]}}