{"entity":{"id":"nct05950139","kind":"trial","name":"Peptide Vaccine To Prevent Acquired Resistance In Patients With Advanced ALK+ NSCLC","aka":["ARCHER"],"tldr":"A phase 1/2 trial in lung cancer, run by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, now recruiting.","summary":"Peptide Vaccine To Prevent Acquired Resistance In Patients With Advanced ALK+ NSCLC is a phase 1/2, interventional study registered as NCT05950139 by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, with a registry enrolment figure of 12 participants, started 2024-05-13 and due to reach its primary completion in 2027-07. Interventions recorded: Peptide vaccine. Conditions listed: NSCLC Stage IV; ALK Fusion Protein Expression. Primary outcome: Incidence of treatment-related adverse events; Vaccine-specific immune response. Lung eligibility wording from the registry: \"Histologically or cytologically confirmed diagnosis of stage IV NSCLC (or recurrent NSCLC not a candidate for definitive multimodality therapy)\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT05950139","url":"https://clinicaltrials.gov/study/NCT05950139"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["alk-positive-nsclc"],"sections":[],"technologies":["shared-antigen-vaccine"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05950139","phase":"1/2","setting":"Pilot Study of a Prophylactic Cancer Peptide Vaccine in Advanced ALK+ NSCLC","sponsor":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins","enrolled":12,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05950139/","neighbours":{"cancer":[{"id":"alk-positive-nsclc","kind":"cancer","name":"ALK-positive non-small-cell lung cancer","route":"/cancers/alk-positive-nsclc/"}],"technology":[{"id":"shared-antigen-vaccine","kind":"technology","name":"Off-the-shelf cancer vaccines","route":"/technologies/shared-antigen-vaccine/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}