{"entity":{"id":"nct05954078","kind":"trial","name":"Circulating Tumor DNA Methylation Guided Postoperative Adjuvant Chemotherapy for High-risk Stage II/III Colorectal Cancer","aka":[],"tldr":"A phase 3 trial in colorectal cancer, run by Fudan University, now recruiting.","summary":"Circulating Tumor DNA Methylation Guided Postoperative Adjuvant Chemotherapy for High-risk Stage II/III Colorectal Cancer is a phase 3, randomised interventional study registered as NCT05954078 by Fudan University, with a registry enrolment figure of 340 participants, started 2023-08-01 and due to reach its primary completion in 2026-06. Interventions recorded: mFOLFIRINOX adjuvant chemotherapy; mFOLFOX6/XELOX adjuvant chemotherapy. Conditions listed: High-risk Stage II Colorectal Cancer; Stage III Colorectal Cancer; Circulating Tumor DNA Methylation. Primary outcome: ctDNA clearance rate. Colorectal eligibility wording from the registry: \"Patients who have been histopathologically diagnosed with colorectal adenocarcinoma;\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05954078","url":"https://clinicaltrials.gov/study/NCT05954078"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["mrd-testing"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05954078","phase":"3","setting":"Circulating Tumor DNA Methylation Guided Postoperative Adjuvant Chemotherapy for High-risk Stage II/III Colorectal Cancer: A Multicenter, Prospective, Randomized Controlled Cohort Study (FINE Trial)","sponsor":"Fudan University","enrolled":340,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05954078/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"mrd-testing","kind":"technology","name":"MRD / molecular residual disease testing","route":"/technologies/mrd-testing/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}