{"entity":{"id":"nct05959356","kind":"trial","name":"Cetuximab and Envafolimab Plus mFOLFOXIRI as First-line Treatment for RAS/BRAF Wild-type, MSS, Unresectable Left-side Metastatic Colorectal Cancer","aka":["CEIL"],"tldr":"A phase 2 trial in colorectal cancer, run by Sun Yat-sen University, now recruiting.","summary":"Cetuximab and Envafolimab Plus mFOLFOXIRI as First-line Treatment for RAS/BRAF Wild-type, MSS, Unresectable Left-side Metastatic Colorectal Cancer is a phase 2, randomised interventional study registered as NCT05959356 by Sun Yat-sen University, with a registry enrolment figure of 198 participants, started 2023-11-09 and due to reach its primary completion in 2026-12-31. Interventions recorded: Cetuximab + Envafolimab + mFOLFOXIRI; Cetuximab + mFOLFOX6. Conditions listed: Metastatic Colorectal Cancer. Primary outcome: Progression free survival. Colorectal eligibility wording from the registry: \"* Patients have histologically or cytologically confirmed RAS and BRAF wild-type, MSS metastatic colorectal adenocarcinoma (mCRC), excluding appendiceal and anal cancers\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05959356","url":"https://clinicaltrials.gov/study/NCT05959356"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05959356","phase":"2","setting":"Cetuximab and Envafolimab Plus mFOLFOXIRI Versus Cetuximab Plus mFOLFOX6 as First-line Treatment for RAS/BRAF Wild-type, MSS, Unresectable Left-side Metastatic Colorectal Cancer: A Randomized Controlled Phase II Trial (CEIL)","sponsor":"Sun Yat-sen University","enrolled":198,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05959356/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}