{"entity":{"id":"nct05965531","kind":"trial","name":"Treating Locally Advanced Rectal Cancer With TAS-102 Chemotherapy Plus Neoadjuvant Radiotherapy","aka":["TASLARC"],"tldr":"A phase 2 trial of trifluridine/tipiracil in colorectal cancer, run by Sun Yat-sen University, now recruiting.","summary":"Treating Locally Advanced Rectal Cancer With TAS-102 Chemotherapy Plus Neoadjuvant Radiotherapy is a phase 2, interventional study registered as NCT05965531 by Sun Yat-sen University, with a registry enrolment figure of 65 participants, started 2024-01-01 and due to reach its primary completion in 2028-12-31. Interventions recorded: Trifluridine/Tipiracil; intensity-modulated radiotherapy. Conditions listed: Rectal Cancer. Primary outcome: Objective response rate. Colorectal eligibility wording from the registry: \"* Pathologically diagnosed rectal adenocarcinoma via biopsy\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05965531","url":"https://clinicaltrials.gov/study/NCT05965531"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","imrt-igrt"],"targets":[],"drugs":["trifluridine-tipiracil"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05965531","phase":"2","setting":"A Single-arm, Phase II Clinical Trial to Treat Locally Advanced, pMMR Rectal Cancer With Single-agent Trifluridine/Tipiracil Chemotherapy Plus Neoadjuvant Intensity-modulated Radiotherapy","sponsor":"Sun Yat-sen University","enrolled":65,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05965531/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"drug":[{"id":"trifluridine-tipiracil","kind":"drug","name":"Trifluridine/tipiracil","route":"/drugs/trifluridine-tipiracil/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}