{"entity":{"id":"nct05972720","kind":"trial","name":"A Phase 2 Study of Firi-cel in Patients With Relapsed/Refractory Large B-cell Lymphoma","aka":[],"tldr":"A phase 2 trial of Firicabtagene autoleucel run by CARGO Therapeutics, terminated.","summary":"A Phase 2 Study of Firi-cel in Patients With Relapsed/Refractory Large B-cell Lymphoma is a phase 2 interventional study registered as NCT05972720 by CARGO Therapeutics, with 101 participants enrolled, started 2023-08-01. Conditions recorded: Cancer and Relapsed/Refractory Large B-cell Lymphoma (LBCL). Interventions recorded: Fludarabine (Conditional therapy), Cyclophosphamide Monohydrate (Conditional therapy) and firi-cel (Experimental drug).","status":"historic","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT05972720","url":"https://clinicaltrials.gov/study/NCT05972720"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer","non-hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":["firicabtagene-autoleucel"],"companies":["cargo-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05972720","phase":"2","setting":"An Open-label, Multicenter Phase 2 Study Evaluating the Efficacy and Safety of Firi-cel, a CD22-directed Autologous Chimeric Antigen Receptor (CAR) T-cell Therapy in Patients With Relapsed/Refractory Large B-Cell Lymphoma After CD19-directed CAR T-cell Therapy","sponsor":"CARGO Therapeutics","enrolled":101,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05972720/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}],"drug":[{"id":"firicabtagene-autoleucel","kind":"drug","name":"Firicabtagene autoleucel","route":"/drugs/firicabtagene-autoleucel/"}],"company":[{"id":"cargo-therapeutics","kind":"company","name":"CARGO Therapeutics","route":"/companies/cargo-therapeutics/"}]}}