{"entity":{"id":"nct05985109","kind":"trial","name":"KN 046 Plus Regorafenib in MSS Metastatic Colorectal Cancer","aka":[],"tldr":"A phase 2 trial of regorafenib in colorectal cancer, run by Peking University Cancer Hospital & Institute, now recruiting.","summary":"KN 046 Plus Regorafenib in MSS Metastatic Colorectal Cancer is a phase 2, interventional study registered as NCT05985109 by Peking University Cancer Hospital & Institute, with a registry enrolment figure of 98 participants, started 2023-10-26 and due to reach its primary completion in 2026-12-31. Interventions recorded: KN046; regorafenib. Conditions listed: Colorectal Cancer. Primary outcome: Overall response rate. Colorectal eligibility wording from the registry: \"Histologically confirmed colorectal adenocarcinoma, including signet ring cell carcinoma and mucinous adenocarcinoma\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05985109","url":"https://clinicaltrials.gov/study/NCT05985109"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["antiangiogenic","kinase-inhibitors"],"targets":[],"drugs":["regorafenib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05985109","phase":"2","setting":"A Phase II Multi-cohort Clinical Study Evaluating The Efficacy and Safety of KN046 in Combination With Regorafenib for Metastatic Microsatellite-Stable Colorectal Cancer: a Phase II Multi-cohort Study","sponsor":"Peking University Cancer Hospital & Institute","enrolled":98,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05985109/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"antiangiogenic","kind":"technology","name":"Anti-angiogenic therapy","route":"/technologies/antiangiogenic/"},{"id":"kinase-inhibitors","kind":"technology","name":"Small-molecule kinase inhibitors","route":"/technologies/kinase-inhibitors/"}],"drug":[{"id":"regorafenib","kind":"drug","name":"Regorafenib","route":"/drugs/regorafenib/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}