{"entity":{"id":"nct05998122","kind":"trial","name":"Total Neoadjuvant Chemoradiotherapy Plus Anti-PD-1 in Subperitoneal Patients With Locally Advanced Rectal CancerPatients With Locally Advanced Rectal Cancer: A","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by The First Hospital of Jilin University, not yet recruiting.","summary":"Total Neoadjuvant Chemoradiotherapy Plus Anti-PD-1 in Subperitoneal Patients With Locally Advanced Rectal CancerPatients With Locally Advanced Rectal Cancer: A Prospective, Single Arm, Exploratory Study is a phase 2, interventional study registered as NCT05998122 by The First Hospital of Jilin University, with a registry enrolment figure of 45 participants, started 2023-09-01 and due to reach its primary completion in 2026-12-31. Interventions recorded: nCRT → (CapeOX+Sintilimab)×6 → Surgery/W&W. Conditions listed: Locally Advanced Rectal Cancer; Total Neoadjuvant Treatment; Anti-PD-1. Primary outcome: Complete response rate (CR). Colorectal eligibility wording from the registry: \"Pathologically diagnosed rectal adenocarcinoma: differentiated into Grade 1-3, that is, high, medium, and poorly differentiated tubular adenocarcinoma; classified as pMMR/MSS\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05998122","url":"https://clinicaltrials.gov/study/NCT05998122"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05998122","phase":"2","setting":"Total Neoadjuvant Chemoradiotherapy Plus Anti-PD-1 in Subperitoneal High-Risk or Very High-Risk Patients With Locally Advanced Rectal Cancer: A Prospective, Single Arm, Exploratory Study","sponsor":"The First Hospital of Jilin University","enrolled":45,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05998122/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}