{"entity":{"id":"nct06010303","kind":"trial","name":"A Study to Evaluate LBL-007 in Combination With Tislelizumab Plus Chemotherapy in Participants With Unresectable Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma","aka":[],"tldr":"A phase 2 trial of Alcestobart run by BeiGene, completed.","summary":"A Study to Evaluate LBL-007 in Combination With Tislelizumab Plus Chemotherapy in Participants With Unresectable Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma is a phase 2 interventional study registered as NCT06010303 by BeiGene, with 118 participants enrolled, started 2023-11-08. Conditions recorded: Esophageal Cancer, Esophageal Squamous Cell Carcinoma and Esophageal Squamous Cell Carcinoma by AJCC V8 Stage. Interventions recorded: LBL-007, Tislelizumab and Chemotherapy Doublet.","status":"completed","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT06010303","url":"https://clinicaltrials.gov/study/NCT06010303"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["esophageal","oesophageal-squamous-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":["alcestobart"],"companies":["nanjing-leads-biolabs"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06010303","phase":"2","setting":"A Phase 2, Randomized, Active-Controlled, Open-Label Study to Evaluate the Efficacy and Safety of LBL-007 in Combination With Tislelizumab Plus Chemotherapy as First-Line Treatment in Patients With Unresectable Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma","sponsor":"BeiGene","enrolled":118,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06010303/","neighbours":{"cancer":[{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"oesophageal-squamous-cell-carcinoma","kind":"cancer","name":"Oesophageal squamous cell carcinoma","route":"/cancers/oesophageal-squamous-cell-carcinoma/"}],"drug":[{"id":"alcestobart","kind":"drug","name":"Alcestobart","route":"/drugs/alcestobart/"}],"company":[{"id":"nanjing-leads-biolabs","kind":"company","name":"Nanjing Leads Biolabs","route":"/companies/nanjing-leads-biolabs/"}]}}