{"entity":{"id":"nct06030622","kind":"trial","name":"Phase 2A Pilot C3 Trial of Recurrent/Refractory Metastatic Advanced Pancreatic Cancer","aka":["C3"],"tldr":"A phase 1/2 trial of gemcitabine in pancreatic cancer, run by State University of New York - Downstate Medical Center, now recruiting.","summary":"Phase 2A Pilot C3 Trial of Recurrent/Refractory Metastatic Advanced Pancreatic Cancer is a phase 1/2, interventional study registered as NCT06030622 by State University of New York - Downstate Medical Center, with a registry enrolment figure of 25 participants, started 2024-04-17 and due to reach its primary completion in 2028-12-01. Interventions recorded: Gemcitabine and C3 (Metformin, Simvastatin, and Digoxin); C3 (Metformin, Simvastatin, and Digoxin) only. Conditions listed: Pancreatic Cancer Metastatic. Primary outcome: Primary Outcome: Safety and tolerability. Pancreatic eligibility wording from the registry: \"Subject ≥18 years with histologically confirmed pancreatic cancer\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06030622","url":"https://clinicaltrials.gov/study/NCT06030622"}],"tags":["ctgov-ingest","pancreatic-deep-dive"],"related":[],"cancers":["metastatic-pdac"],"sections":[],"technologies":["cytotoxic-chemotherapy"],"targets":[],"drugs":["gemcitabine"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06030622","phase":"1/2","setting":"Phase 2A Pilot Trial of Metformin, Digoxin, Simvastatin (C3) in Combination With Gemcitabine in Subjects With Recurrent / Refractory Metastatic Advanced Pancreatic Cancer","sponsor":"State University of New York - Downstate Medical Center","enrolled":25,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06030622/","neighbours":{"cancer":[{"id":"metastatic-pdac","kind":"cancer","name":"Metastatic pancreatic ductal adenocarcinoma","route":"/cancers/metastatic-pdac/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"}],"drug":[{"id":"gemcitabine","kind":"drug","name":"Gemcitabine","route":"/drugs/gemcitabine/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}