{"entity":{"id":"nct06031558","kind":"trial","name":"Phase III Study of SY-5007, a RET Inhibitor, in Patients With Locally Advanced or Metastatic RET Fusion-positive NSCLC","aka":[],"tldr":"A phase 3 trial in lung cancer, run by Shouyao Holdings (Beijing) Co. LTD, active but no longer recruiting.","summary":"Phase III Study of SY-5007, a RET Inhibitor, in Patients With Locally Advanced or Metastatic RET Fusion-positive NSCLC is a phase 3, interventional study registered as NCT06031558 by Shouyao Holdings (Beijing) Co. LTD, with a registry enrolment figure of 120 participants, started 2023-10-31 and due to reach its primary completion in 2025-04-10. Interventions recorded: SY-5007. Conditions listed: Non-Small Cell Lung Cancer. Primary outcome: Assessment of ORR by independent review committee (IRC).. Lung eligibility wording from the registry: \"Histologically or cytologically confirmed diagnosis of locally advanced (with a tumor lesion that cannot be eradicated by surgery or radiotherapy as assessed by the investigators) or metastatic NSCLC\". Sites: China. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT06031558","url":"https://clinicaltrials.gov/study/NCT06031558"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["ret-fusion-nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06031558","phase":"3","setting":"A Phase III, Open-Label, Single-arm, Multicenter Study to Evaluate the Efficacy and Safety of SY-5007, a RET Inhibitor, in Patients With Locally Advanced or Metastatic RET Fusion-positive NSCLC.","sponsor":"Shouyao Holdings (Beijing) Co. LTD","enrolled":120,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06031558/","neighbours":{"cancer":[{"id":"ret-fusion-nsclc","kind":"cancer","name":"RET fusion-positive non-small-cell lung cancer","route":"/cancers/ret-fusion-nsclc/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}