{"entity":{"id":"nct06099951","kind":"trial","name":"Total Neoadjuvant Treatment for pMMR Locally Advanced Low Rectal Cancer: Anti-PD-1 Antibody With FOLFOXIRI and Preoperative Radiation Therapy","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Sun Yat-sen University, not yet recruiting.","summary":"Total Neoadjuvant Treatment for pMMR Locally Advanced Low Rectal Cancer: Anti-PD-1 Antibody With FOLFOXIRI and Preoperative Radiation Therapy is a phase 2, interventional study registered as NCT06099951 by Sun Yat-sen University, with a registry enrolment figure of 53 participants, started 2023-11-01 and due to reach its primary completion in 2024-09-01. Interventions recorded: Serplulimab + FOLFOXIRI; Radiation therapy. Conditions listed: Colorectal Cancer. Primary outcome: Complete tumor response rate.. Colorectal eligibility wording from the registry: \"* The pathological confirmation is rectal adenocarcinoma\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06099951","url":"https://clinicaltrials.gov/study/NCT06099951"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06099951","phase":"2","setting":"Single Arm Phase II Clinical Trial of Recombinant Humanized Anti PD-1 Monoclonal Antibody and FOLFOXIRI Regimen Combined With Preoperative Intensity Modulated Radiation Therapy as the Total Neoadjuvant Treatment for pMMR Locally Advanced Low Rectal Cancer","sponsor":"Sun Yat-sen University","enrolled":53,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06099951/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}