{"entity":{"id":"nct06106308","kind":"trial","name":"Study of Onvansertib in Combination With FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab fo","aka":[],"tldr":"A phase 2 trial of FOLFIRI, Bevacizumab, FOLFOX in colorectal cancer, run by Cardiff Oncology, active and no longer recruiting.","summary":"Study of Onvansertib in Combination With FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer in Adult Participants With a KRAS or NRAS Mutation is a phase 2 interventional study registered as NCT06106308 by Cardiff Oncology, with 110 participants enrolled, started 2024-02-27 and due to reach its primary completion in 2026-11. Interventions recorded: Onvansertib, FOLFIRI, Bevacizumab, FOLFOX. Conditions listed: Metastatic Colorectal Cancer, CRC, KRAS/NRAS Mutation. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT06106308","url":"https://clinicaltrials.gov/study/NCT06106308"}],"tags":["ctgov-ingest"],"related":[],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["folfiri","bevacizumab","folfox"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT06106308","phase":"2","setting":"A Phase 2, Randomized, Open-label Study of Onvansertib in Combination With FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab for First-line Treatment of Metastatic Colorectal Cancer in Patients With a KRAS or NRAS Mutation","sponsor":"Cardiff Oncology","enrolled":110,"outcomes":[]},"route":"/trials/nct06106308/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"drug":[{"id":"bevacizumab","kind":"drug","name":"Bevacizumab","route":"/drugs/bevacizumab/"},{"id":"folfiri","kind":"drug","name":"FOLFIRI (5-FU, leucovorin, irinotecan)","route":"/drugs/folfiri/"},{"id":"folfox","kind":"drug","name":"FOLFOX (5-FU, leucovorin, oxaliplatin)","route":"/drugs/folfox/"},{"id":"onvansertib","kind":"drug","name":"Onvansertib","route":"/drugs/onvansertib/"}]}}