{"entity":{"id":"nct06107868","kind":"trial","name":"Phase 1 Study of RP-6306 With Carboplatin and Paclitaxel in TP53 Ovarian and Uterine Cancer","aka":[],"tldr":"A phase 1 trial of Lunresertib run by University Health Network, Toronto, active and no longer recruiting.","summary":"Phase 1 Study of RP-6306 With Carboplatin and Paclitaxel in TP53 Ovarian and Uterine Cancer is a phase 1 interventional study registered as NCT06107868 by University Health Network, Toronto, with 6 participants planned, started 2024-03-20. Conditions recorded: Recurrent Ovarian Cancer, Recurrent Uterine Cancer, Metastatic Cancer and Advanced Cancer. Interventions recorded: RP-6306, Carboplatin and Paclitaxel.","status":"active","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT06107868","url":"https://clinicaltrials.gov/study/NCT06107868"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["ovarian","endometrial","metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["lunresertib"],"companies":["repare-therapeutics","debiopharm"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06107868","phase":"1","setting":"Phase I Study of the PKMYT1 Inhibitor RP-6306 in Combination With Carboplatin and Paclitaxel for the Treatment of Recurrent TP53 Ovarian and Uterine Cancer","sponsor":"University Health Network, Toronto","enrolled":6,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06107868/","neighbours":{"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"drug":[{"id":"lunresertib","kind":"drug","name":"Lunresertib","route":"/drugs/lunresertib/"}],"company":[{"id":"debiopharm","kind":"company","name":"Debiopharm","route":"/companies/debiopharm/"},{"id":"repare-therapeutics","kind":"company","name":"Repare Therapeutics","route":"/companies/repare-therapeutics/"}]}}