{"entity":{"id":"nct06185556","kind":"trial","name":"COLDFIRE-III Trial: Efficacy of Irreversible Electroporation and Stereotactic Body Radiotherapy for Perivascular and Peribiliary Colorectal Liver Metastases","aka":["COLDFIRE-III"],"tldr":"A phase 2/3 trial in colorectal cancer, run by Amsterdam UMC, location VUmc, now recruiting.","summary":"COLDFIRE-III Trial: Efficacy of Irreversible Electroporation and Stereotactic Body Radiotherapy for Perivascular and Peribiliary Colorectal Liver Metastases is a phase 2/3, randomised interventional study registered as NCT06185556 by Amsterdam UMC, location VUmc, with a registry enrolment figure of 78 participants, started 2024-08-20 and due to reach its primary completion in 2029-09-01. Interventions recorded: Irreversible electroporation; Stereotactic body radiotherapy. Conditions listed: Colorectal Cancer; Liver Metastases; Liver Metastasis Colon Cancer; Unresectable Solid Tumor. Primary outcome: Local control. Colorectal eligibility wording from the registry: \"* Histological documentation of primary colorectal tumor is available;\". Sites: Netherlands. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06185556","url":"https://clinicaltrials.gov/study/NCT06185556"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["colon-cancer"],"sections":[],"technologies":["sbrt"],"targets":[],"drugs":[],"companies":["angiodynamics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06185556","phase":"2/3","setting":"COLDFIRE-III Trial: Perivascular and Peribiliary Colorectal Liver Metastases (0-5cm): Irreversible Electroporation Versus Stereotactic Body Radiotherapy","sponsor":"Amsterdam UMC, location VUmc","enrolled":78,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06185556/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"}],"technology":[{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"}],"company":[{"id":"angiodynamics","kind":"company","name":"AngioDynamics","route":"/companies/angiodynamics/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}