{"entity":{"id":"nct06188468","kind":"trial","name":"ImmunoPET Targeting Trop-2 in Solid Tumors (68Ga-MY6349)","aka":[],"tldr":"The Xiamen study that first imaged the TROP2 protein in 90 patients with 15 kinds of cancer using a new PET scan.","summary":"NCT06188468 evaluated the feasibility of 68Ga-MY6349 PET/CT for non-invasive assessment of Trop2 expression across cancer types, with the aim of identifying patients who might benefit from Trop-2-targeted antibody-drug conjugates. Results were published in the Journal of Clinical Investigation in 2024: uptake correlated with Trop2 immunohistochemistry and was higher than FDG in breast, prostate and thyroid cancer.","status":"completed","asOf":"2026-11-04","links":[{"label":"ClinicalTrials.gov NCT06188468","url":"https://clinicaltrials.gov/study/NCT06188468"},{"label":"Chen et al., J Clin Invest 2024","url":"https://doi.org/10.1172/jci185408"}],"tags":[],"related":[],"cancers":["breast-cancer"],"sections":[],"technologies":["trop2-pet"],"targets":["trop2"],"drugs":["ga68-my6349"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-chen-ga68-my6349-jci-2024"],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06188468","phase":"not-applicable","setting":"Patients with solid tumours: 68Ga-MY6349 PET/CT compared with standard-of-care imaging (18F-FDG, 68Ga-PSMA or 68Ga-DOTATATE PET/CT)","sponsor":"The First Affiliated Hospital of Xiamen University","result":"Uptake correlated with Trop2 immunohistochemistry; breast cancer SUVmax 7.2 vs 5.4 with FDG.","started":"2023-10-01","startedType":"actual","yearReported":2024,"enrolled":90,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06188468/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}],"technology":[{"id":"trop2-pet","kind":"technology","name":"TROP2 PET","route":"/technologies/trop2-pet/"}],"target":[{"id":"trop2","kind":"target","name":"TROP2","route":"/targets/trop2/"}],"drug":[{"id":"ga68-my6349","kind":"drug","name":"68Ga-MY6349","route":"/drugs/ga68-my6349/"}],"paper":[{"id":"paper-chen-ga68-my6349-jci-2024","kind":"paper","name":"68Ga-MY6349 PET/CT imaging to assess Trop2 expression in multiple types of cancer","route":"/key-papers/paper-chen-ga68-my6349-jci-2024/"}]}}