{"entity":{"id":"nct06195670","kind":"trial","name":"Clinical Study of Short-course Radiotherapy Followed by Fruquintinib Plus Sintilimab vs Bevacizumab Plus Capecitabine as First Line Treatment in Advanced mCRC","aka":[],"tldr":"A phase 1/2 trial in colorectal cancer, run by Zhejiang Cancer Hospital, not yet recruiting.","summary":"Clinical Study of Short-course Radiotherapy Followed by Fruquintinib Plus Sintilimab vs Bevacizumab Plus Capecitabine as First Line Treatment in Advanced mCRC is a phase 1/2, randomised interventional study registered as NCT06195670 by Zhejiang Cancer Hospital, with a registry enrolment figure of 220 participants, started 2024-01 and due to reach its primary completion in 2026-01. Interventions recorded: Experimental; Active Comparator. Conditions listed: CRC; Metastatic Colorectal Cancer; Metastatic Colorectal Adenocarcinoma. Primary outcome: Phase 1b - Objective Response Rate (ORR); Phase 2 - Progression-free Survival (PFS). Colorectal eligibility wording from the registry: \"* Histopathologically confirmed unresectable advanced metastatic colorectal adenocarcinoma;\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06195670","url":"https://clinicaltrials.gov/study/NCT06195670"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06195670","phase":"1/2","setting":"An Open-label, Multi-centered, Two-stage Clinical Study of Short-course Radiotherapy Followed by Fruquintinib Plus Sintilimab vs Bevacizumab Plus Capecitabine in the First Line Treatment of Advanced mCRC Patients Unfit for Intense Therapy","sponsor":"Zhejiang Cancer Hospital","enrolled":220,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06195670/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}